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HomeEndpoint Security (XDR/EDR)CompareCisco Secure Endpoint vs Trellix
Updated May 13, 2026 · Independent Analysis

Cisco Secure EndpointvsTrellix

Capability Overview
Cisco Secure Endpoint logo - software comparison
4.2/5-0.1 vs Trellix
Only in Cisco Secure Endpoint
  • Next-Gen Antivirus
  • EDR (Endpoint Detection & Response)
  • Device Trajectory
From $24/moFortune 500 users · est. 1984
Trellix logo - software comparison
Trellixvs Cisco Secure Endpoint
4.3/5+0.1 vs Cisco Secure Endpoint
Only in Trellix
  • XDR Platform (Trellix XDR)
  • Endpoint Security (ENS)
  • EDR
40k+ users · est. 2022

Real-World Scenarios: When to Choose Which

The question that matters: “In what situation will I regret choosing A over B after 3 months?”

Scenario: Zero Trust Network Access via
Cisco Secure Endpoint
Zero Trust Network Access via Cisco Duo MFA

Cisco Duo enforces MFA and device trust checks before every application access, blocking 99.9% of account compromise attempts on applications that previously relied on password-only authentication.

Trellix
Cross-Vector Correlation Across Email, Endpoint, and Network

Trellix XDR correlates detections from email security, endpoint, and network sensors into a unified incident, reducing the time to connect a phishing email to its endpoint execution from hours to minutes.

Cisco Secure Endpoint Unique Strength
Umbrella DNS Filtering for Remote Workers Without VPN

Cisco Umbrella blocks malicious domains at the DNS layer for off-network devices, providing threat protection to remote workers without routing all traffic through a central VPN gateway.

→ Choose Cisco Secure Endpoint if this scenario applies to you. Trellix doesn't offer a comparable solution.
Cisco Secure Endpoint Unique Strength
XDR Correlation Across Cisco and Third-Party Telemetry

Cisco XDR ingests data from Secure Endpoint, Firewall, and third-party SIEM sources, correlating events into incident stories with MITRE ATT&CK mapping and suggested response actions.

→ Choose Cisco Secure Endpoint if this scenario applies to you. Trellix doesn't offer a comparable solution.
Trellix Unique Strength
Automated SOAR Playbook Execution on High-Confidence Detections

Trellix's native SOAR playbooks execute containment steps like user account suspension and host isolation automatically on high-confidence detections, reducing analyst workload on routine incidents.

→ Choose Trellix if this scenario applies to you. Cisco Secure Endpoint doesn't offer a comparable solution.
Trellix Unique Strength
Threat Intelligence Filtered to Your Industry by Trellix Insights

Trellix Insights pre-filters threat intelligence to the vulnerabilities and techniques relevant to your industry, reducing the volume of raw intel to actionable prioritization for patching and detection tuning.

→ Choose Trellix if this scenario applies to you. Cisco Secure Endpoint doesn't offer a comparable solution.

Pricing Intelligence

Cisco Secure Endpoint logo - software comparison

Cisco Secure Endpoint Plans

Paid plans only

EssentialsBest Value
$24/device/yr
  • Next-gen AV
  • Basic EDR
  • Threat intelligence
Advantage
Custom
  • Full EDR
  • XDR via SecureX
  • Orbital Advanced Search
Full Cisco Secure Endpoint Pricing Breakdown →
Trellix logo - software comparison

Trellix Plans

Paid plans only

Enterprise
Custom
  • Trellix XDR
  • Threat intelligence
  • Helix SIEM
Full Trellix Pricing Breakdown →

Feature Matrix

4 differences found across 15 standardized features

Feature
Cisco Secure Endpoint
Trellix
Identity Threat Detection
Zero Trust
Firewall
Deception Technology
Total (raw)
16
16

Pros & Cons Face-Off

Evaluative strengths and weaknesses — not feature lists

Pros
  • +Talos threat intelligence processes billions of daily threat events
  • +Deep integration with Cisco networking for network context in EDR
  • +SecureX provides unified XDR across the Cisco portfolio
  • +95% of Fortune 500 are Cisco customers -- easy expansion
Cons
  • Endpoint-specific product less innovative than pure-play EDR vendors
  • Best value only for existing Cisco security ecosystem customers
Pros
  • +40k+ enterprise customers provide strong market credibility
  • +Broad XDR coverage across endpoint, email, network, cloud
  • +Helix SIEM/SOAR integration
  • +FireEye legacy threat intelligence
Cons
  • Post-merger integration has slowed product innovation
  • Mandiant threat intelligence asset moved to Google

At a Glance

User Rating
4.2/5vs4.3/5
Cisco Secure Endpoint
Trellix
Starting Price
$24/movsContact
Cisco Secure Endpoint
Trellix
Feature Count
16 featuresvs16 features
Cisco Secure Endpoint
Trellix
User Base
500vs40
Cisco Secure Endpoint
Trellix

Frequently Asked Questions

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Authored by Oleh KemExpert verified·Updated May 13, 2026·Our methodology